Matthew is a Professor of Molecular Bacteriology and his research focuses on studying AMR in bacteria, using molecular genetics, biochemistry and functional genomics techniques to identify and characterise AMR mechanisms in key human pathogens, their mobilisation, and their control. This information is used to help to combat the problem of AMR by developing interdisciplinary research collaborations. Matthew leads the Bristol AMR interdisciplinary AMR research network which spans all 6 Faculties at the University of Bristol (funded by Wellcome ISSF). Matthew leads the NERC/BBSRC/MRC ‘One Health Health Selection and Transmission of Antimicrobial Resistance’ (OH-STAR) consortium, working with clinicians in Bristol’s two NHS Trusts to use whole genome sequencing (WGS) to survey urinary E. coli and all Gram-negative bacteria from bloodstream infections in the south west region. The project is monitoring ecological shifts resulting from local prescribing policy changes, to inform empiric prescribing and IV/oral switch for sepsis. The project also aims to 1) to identify how changes in prescribing practice in primary care can alter the prevalence of AMR infections in humans; 2) define the environmental and management factors that influence acquisition and selection of AMR bacteria in dairy cattle and in dogs and 3) to identify whether AMR bacteria from these animals impacts on AMR in human infections. The MRC/DoHSC ‘One Health Drivers of Antibacterial Resistance in Thailand’ (OH-DART) consortium is also led by Matthew with co-investigators at the Universities of Bath and Exeter, the UK Centre for Ecology and Hydrology, Mahidol University and the Chulaborn Research Institute in Thailand.
Kristen is a veterinarian and Reader in Veterinary Epidemiology and Population Health at the Bristol Vet School, where she leads an interdisciplinary research group (the AMR Force). AMR Force is focused on AMR and the responsible use of antimicrobials in livestock farming and veterinary practice. Kristen holds a DoHSC GAMRIF/CONICET UK-Argentina award looking at future-proofing antibacterial resistance risk management surveillance and stewardship in the Argentinian farming environment (FARMS-SAFE project). She is a Co-I on the ESRC-led cross-council AMR Theme 4 ‘Diagnostic Innovation and Livestock’ (DIAL) consortium award (led by Exeter) which is working towards more effective and sustainable applications of antibiotics in livestock farming. Kristen is also a Co-I on the NERC/BBSRC/MRC cross council AMR Theme 3 OH-STAR consortium and the MRC/DoHSC-funded OH-DART consortium (both led by Bristol) studying the One Health drivers of antibacterial resistance in the UK and Thailand, respectively.